Subaortic Stenosis, also known as Subvalvular Aortic Stenosis, is a common and potentially fatal inherited heart defect that can be found in several dog breeds, including the Bouvier Des Flandres. SAS is caused by abnormal tissue located just below the aortic valve, which obstructs the path for the outflow of blood from the heart to the circulation, creating a partial blockage. As a result, the heart works harder to maintain normal circulation, putting an increased strain on the main pumping chamber of the heart, the left ventricle.

SAS can be mild, moderate, or severe. Dogs with mild SAS may be asymptomatic. However, in moderate and severe cases, the dog may experience any of the following symptoms: weakness, breathing difficulty, fainting, and, sudden death.

SAS is hereditary, but so far there are no known genetic markers. The BHF has been collaborating with Dr. Joshua Stern PhD, DVM, ACVIM, a cardiologist, since 2015 to conduct research on SAS. The goal is to identify the genetic markers responsible for this disease and remove all affected dogs from the breeding pool to prevent the spread of the lesion within the population.

Read more on Dr. Sterns.

Dr. Sterns work is incredibly important for our breed. By studying the genetic foundation of inherited heart conditions like SAS, we can better our breeding lines and ultimately boost the overall health of our dogs. Moreover, this research can help us acquire the essential information to develop drug therapies that target the affected genes.

If your dog has a cardiac murmur or abnormal echocardiogram and your vet is concerned about SAS, the Bouvier Health Foundation will cover the expenses related to obtaining the necessary testing and information needed for your dog to participate in Dr. Stern’s research. If you have any questions or concerns, please don’t hesitate to contact the BHF. Review the paperwork required for Dr. Sterns research.